| 改进的偏最小二乘-近红外光谱法非破坏定量分析Cofrel药品 |
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| 引用本文： | 刘名扬,孟昱,任玉林,张寒琦.改进的偏最小二乘-近红外光谱法非破坏定量分析Cofrel药品[J].光谱学与光谱分析,2007,27(6):1098-1101. |
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| 作者姓名： | 刘名扬 孟昱 任玉林 张寒琦 |
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| 作者单位： | 吉林大学化学学院,吉林,长春,130012;辉瑞制药有限公司,辽宁,大连,116600 |
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| 基金项目： | 国家自然科学基金
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吉林省科技厅科研项目 |
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| 摘 要： | 用改进的偏最小二乘法解析Cofrel药品的近红外漫反射光谱，实现了对其有效成分磷酸苯丙哌林精确的非破坏定量测定。用主成分得分趋势图选择最佳主成分数。讨论了波长范围及原始光谱、一阶导数光谱、二阶导数光谱对测定结果的影响。用HPLC法的测定结果作标准，磷酸苯丙哌林预测值的相对误差RE(%)＜0.42，满足Cofrel药品实际生产的测定要求。
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| 关 键 词： | 偏最小二乘 近红外光谱 主成分 非破坏定量分析 Cofrel(科福乐)药品 |
| 文章编号： | 1000-0593（2007）06-1098-04 |
| 收稿时间： | 2006-05-10 |
| 修稿时间： | 2006-05-102006-08-20 |
Nondestructive Quantitative Analysis of Cofrel Medicines by Improved Partial Least Squares-NIR Spectroscopy |
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| LIU Ming-yang,MENG yu,REN Yu-lin,ZHANG Han-qi.Nondestructive Quantitative Analysis of Cofrel Medicines by Improved Partial Least Squares-NIR Spectroscopy[J].Spectroscopy and Spectral Analysis,2007,27(6):1098-1101. |
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| Authors: | LIU Ming-yang MENG yu REN Yu-lin ZHANG Han-qi |
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| Institution: | 1. College of Chemistry，Jilin University，Changchun 130023，China2. Prefz Pharmaceutical Co.，Dalian 116600，China |
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| Abstract: | In the present paper,improved partial least squares(PLS) method was used to parse near infrared(NIR) reflectance spectrum of Cofrel medicine.The contents of benproperine phosphate,a availability pharmaceutical in Cofrel medicine,were accurately nondestructively quantitatively predicted.The best number of principal components(PC) was designed by scores plot of samples in PC.The effects of the wavelength range,conventional spectra,first-derivative spectra and second-derivative spectra on the results were discussed respectively.Comparing the results with those of HPLC,the relative errors(RE%) of benproperine phosphate were less than 0.42%.The analytical results were sufficient for practical manufacture of Cofrel medicine. |
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| Keywords: | Partial least squares(PLS) Near infrared spectroscopy Principal components(PC) Nondestructive quantitative analysis Cofrel |
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