Synthesis,antibacterial, anticancer and molecular docking studies of macrocyclic metal complexes of dihydrazide and diketone |
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| Authors: | Sabir Ali Vandna Singh Preeti Jain Vishwas Tripathi |
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| Affiliation: | 1. Department of Applied Chemistry, School of Vocational Studies and Applied Sciences, Gautam Buddha University, Greater Noida, Uttar Pradesh 201310, India;2. School of Basic Sciences and Research, Sharda University, Greater Noida, Uttar Pradesh 201310, India;3. School of Biotechnology, Gautam Buddha University, Greater Noida, Uttar Pradesh 201310, India |
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| Abstract: | The complexes of Co(II), Ni(II), Cu(II) and Zn(II) metal ions has been synthesized through template method by the condensation of succinic acid dihydrazide with 5-chloroisatin in alcoholic medium. Complexes were characterized by C H N analysis, molar conductance, thermal analysis, magnetic susceptibility, mass spectrometry, FTIR, EPR, 1H NMR, UV–Visible spectroscopy. These studies suggest an octahedral geometry for all the complexes. The compounds were found active against B. subtilis and S. aureus and P. aeruginosa and E. coli bacteria. The Zn(II) complex showed significant anticancer activity against Squamous Cell Carcinoma cells tested by the MTT assay method. Molecular docking studies with EGFR tyrosine kinase were also carried out. All these results show that some of the synthesized compounds have remarkable antibacterial and anticancer property. |
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| Keywords: | Metal complexes Antibacterial activity Anticancer activity Molecular docking with EGFR |
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