Comparative performance study of different sample introduction techniques for rapid and precise selenium isotope ratio determination using multi-collector inductively coupled plasma mass spectrometry (MC-ICP/MS) |
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Authors: | Nagmeddin Elwaer Holger Hintelmann |
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Institution: | (1) Chemistry Department, Trent University, 1600 West Bank Drive, Peterborough, ON, K9J 7B8, Canada |
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Abstract: | The analytical performance of five sample introduction systems, a cross flow nebulizer spray chamber, two different solvent
desolvation systems, a multi-mode sample introduction system (MSIS), and a hydride generation (LI2) system were compared for
the determination of Se isotope ratio measurements using multi-collector inductively coupled plasma mass spectrometry (MC-ICP/MS).
The optimal operating parameters for obtaining the highest Se signal-to-noise (S/N) ratios and isotope ratio precision for
each sample introduction were determined. The hydride generation (LI2) system was identified as the most suitable sample introduction
method yielding maximum sensitivity and precision for Se isotope ratio measurement. It provided five times higher S/N ratios
for all Se isotopes compared to the MSIS, 20 times the S/N ratios of both desolvation units, and 100 times the S/N ratios
produced by the conventional spray chamber sample introduction method. The internal precision achieved for the 78Se/82Se ratio at 100 ng mL−1 Se with the spray chamber, two desolvation, MSIS, and the LI2 systems coupled to MC-ICP/MS was 150, 125, 114, 13, and 7 ppm,
respectively. Instrument mass bias factors (K) were calculated using an exponential law correction function. Among the five
studied sample introduction systems the LI2 showed the lowest mass bias of −0.0265 and the desolvation system showed the largest
bias with −0.0321.
Figure Illustration of the multi-mode sample introduction system for Se isotope ratiomeasurements |
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Keywords: | Multi-collector inductively couple plasma mass spectrometry Multi-mode sample introduction Sample desolvation Hydride generation Selenium Isotope ratio |
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