Asymmetric synthesis of benzylic quaternary difunctionalized carbons mediated by a remote sulfinyl group |
| |
Authors: | Ruano José Luis García Torrente Esther Martín-Castro Ana M |
| |
Affiliation: | Departamento de Qui?mica Orga?nica, Universidad Auto?noma de Madrid, Cantoblanco, 28049 Madrid, Spain. joseluis.garcia.ruano@uam.es |
| |
Abstract: | Enantiomerically enriched α-aryl α-cyanoacetates and α-aryl α-acylacetonitriles bearing a benzylic quaternary stereocenter have been readily synthesized by stereoselective reaction of 2-alkyl-2-[2-(p-tolylsulfinyl)phenyl]acetonitriles with different acylating and alkoxycarbonylating reagents under basic conditions. The stereoselectivity of the reactions proved closely dependent on the nature of the intermediate carbanionic species, the evolution of which was effectively controlled by a sulfinyl group as a remote chiral auxiliary. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|