Synthesis of (S)-7-amino-5-azaspiro[2.4]heptane via highly enantioselective hydrogenation of protected ethyl 1-(2-aminoaceto)cyclopropanecarboxylates |
| |
| Authors: | Yao Ying Fan Weizheng Li Wanfang Ma Xin Zhu Lvfeng Xie Xiaomin Zhang Zhaoguo |
| |
| Institution: | School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China. |
| |
| Abstract: | Highly effective asymmetric hydrogenation of protected ethyl 1-(2-aminoaceto)cyclopropane carboxylates in the presence of RuCl(benzene)(S)-SunPhos]Cl was realized, and high enantioselectivities (up to 98.7% ee) were obtained. This asymmetric hydrogenation provides a key intermediate for the enantioselective synthesis of (S)-7-amino-5-azaspiro2.4]heptane moiety of quinolone antibacterial agents. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
