Fibrillisation of ring-closed amyloid peptides |
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Authors: | Hamley Ian W Cheng Ge Castelletto Valeria Handschin Stephan Mezzenga Raffaele |
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Institution: | Dept of Chemistry, University of Reading, Whiteknights Reading RG6 6AD, UK. I.W.Hamley@reading.ac.uk |
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Abstract: | Ring-closing olefin metathesis reactions are used to create intra-molecularly ring closed peptides or inter-molecularly ring-closed peptide dimers based on a designed amyloid peptide sequence. The uncrosslinked peptide self-assembles into high aspect ratio nanotubes, however ring-closing leads to the formation of fibrillar and twisted/helical ribbon structures. |
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