Determination of non-steroidal anti-inflammatory drugs in wastewaters by magnetic matrix solid phase dispersion-HPLC |
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Authors: | K Aguilar-Arteaga JM Miranda J Medina |
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Institution: | a Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Hidalgo, Carr. Pachuca Tulancingo Km 4.5, 42074, Pachuca, Hgo, Mexico b Departamento de Química Analítica, Nutrición y Bromatología, Facultad de Veterinaria, Universidad de Santiago de Compostela, 27002 Lugo, Spain c QUIANE, Departamento de Química Analítica, Universidad de Valladolid, Prado de la Magdalena s/n, 47005 Valladolid, Spain |
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Abstract: | A series of supports functionalized with different alkyl chains and covered with magnetite were synthesized, characterized and applied in the sample pre-concentration of four non-steroidal anti-inflammatory drugs (acetaminophen, naproxen, diclofenac and ibuprofen) contained in wastewater samples. The general methodology involved magnetic solid phase dispersion followed by the analysis by high-performance liquid chromatography with ultraviolet detection. The magnetic supports were initially dispersed in the samples with the aid of Triton X-100, then supports were magnetically isolated and the analytes were eluted with methanol. Finally the extract was injected into the HPLC system. The highest recovery percentage (>90%) was obtained with the support containing octyl chains (C8) at pH 3. The lowest limits of detection achieved ranged within 1-2 μg L−1 with repeatability (expressed as RSD) below 5% in all cases. The method was applied in the analysis of wastewater samples. |
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Keywords: | Magnetic-MSPD NSAIDs HPLC Magnetic separation |
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