A sensitive choline biosensor with supramolecular architecture |
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| Authors: | Zhanxia Zhang Juan Wang Xiaolei Wang Yong Wang Xiurong Yang |
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| Institution: | a State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Renmin Street 5625, Changchun, Jilin 130022, China
b Graduate School of the Chinese Academy of Sciences, Beijing 100039, China |
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| Abstract: | A sensitive biosensor with supramolecular architecture was designed and implemented here to detect choline. Choline oxidase and horseradish peroxidase were assembled onto the polymer of thiolated β-cyclodextrin and platinum nanoparticles modified gold electrode through 1-adamantane carboxylic acid coupling. Square wave voltammetry showed that the reduction currents at 0.38 mV had a linear relationship with the logarithms of choline concentrations in the range of 10−9-10−2 M, and the detection limit was down to 0.1 nM. Such biosensor also exhibited excellent selectivity, reproducibility and stability. |
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| Keywords: | Choline biosensor Supramolecular complex β-Cyclodextrin Platinum nanoparticles Square wave voltammetry |
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