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Multi-wall carbon nanotubes (MWCNTs)-doped polypyrrole DNA biosensor for label-free detection of genetically modified organisms by QCM and EIS |
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| Authors: | Truong Thi Ngoc Lien Vu Thi Hong An Duong Tuan Quang Dinh Quang Khieu Young Hoon Lee |
| Institution: | a Hanoi University of Technology, Hanoi 8404, Viet Nam b Institute of Materials Science, Vietnamese Academy of Science and Technology, Hanoi 8404, Viet Nam c Hue University, Hue 84054, Viet Nam d Center for Nano Materials and Technology, Japan Advanced Institute of Science and Technology, Ishikawa 923-1292, Japan e Department of Chemistry, Korea University, Anam dong 5-1, Seongbuk gu, Seoul 136-701, Republic of Korea |
| Abstract: | In this paper, we describe DNA electrochemical detection for genetically modified organism (GMO) based on multi-wall carbon nanotubes (MWCNTs)-doped polypyrrole (PPy). DNA hybridization is studied by quartz crystal microbalance (QCM) and electrochemical impedance spectroscopy (EIS). An increase in DNA complementary target concentration results in a decrease in the faradic charge transfer resistance (Rct) and signifying “signal-on” behavior of MWCNTs-PPy-DNA system. QCM and EIS data indicated that the electroanalytical MWCNTs-PPy films were highly sensitive (as low as 4 pM of target can be detected with QCM technique). In principle, this system can be suitable not only for DNA but also for protein biosensor construction. |
| Keywords: | MWCNTs-doped polypyrrole Electrochemical DNA biosensor Quartz crystal microbalance Electrochemical impedance spectroscopy |
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