New biologically active marine sesquiterpenoid and steroid from the okinawan sponge of the genus Axinyssa |
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| Authors: | Iwashima Makoto Terada Ikuo Iguchi Kazuo Yamori Takao |
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| Institution: | School of Life Science, Tokyo University of Pharmacy and Life Science, Hachioji, Japan. |
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| Abstract: | A new bisabolane-type sesquiterpenoid, (E)-3-isocyanobisabolane-7,10-diene (1), and a new epidioxyergostane-type steroid, 9(11)-dehydroaxinysterol (2), were isolated from the Okinawan sponge of the genus Axinyssa. Their structures were elucidated based on the results of spectroscopic analysis and chemical conversion. Epidioxysterol 2 was found to show significant growth inhibitory effects against human cancer cell lines. |
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