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| KF/Al2O3催化下吡啶并[2,3-d]嘧啶衍生物的三组分一步合成 | |
| 引用本文： | 王香善,曾兆森,史达清,屠树江,魏贤勇,宗志敏. KF/Al2O3催化下吡啶并[2,3-d]嘧啶衍生物的三组分一步合成[J]. 有机化学, 2006, 26(2): 256-259 |
| 作者姓名： | 王香善 曾兆森 史达清 屠树江 魏贤勇 宗志敏 |
| 作者单位： | 1. 中国矿业大学化学工程学院,徐州,221008;徐州师范大学化学系,徐州,221116;江苏省药用植物生物技术重点实验室,徐州,221116 2. 徐州师范大学化学系,徐州,221116 3. 徐州师范大学化学系,徐州,221116;江苏省药用植物生物技术重点实验室,徐州,221116 4. 中国矿业大学化学工程学院,徐州,221008 |
| 基金项目： | 江苏省高校自然科学基金(No.04KJB150139)资助项目. |
| 摘 要： | 以芳醛、丙二腈和2,6-二羟基-4-氨基嘧啶为原料, 在KF/Al2O3催化下以乙醇为溶剂, 在80 ℃三组分一步合成了一系列吡啶并[2,3-d]嘧啶衍生物, 有趣的是在空气氧化作用下进一步发生了芳构化作用. 和其它合成方法相比, 该方法具有反应条件温和、容易操作和产率较高等优点, 并通过IR, 1H NMR和元素分析确证产物的结构. |
| 关 键 词： | 吡啶并[2, 3-d]嘧啶 芳构化 KF/Al2O3 合成 |
| 收稿时间： | 2005-02-21 |
| 修稿时间： | 2005-08-05 |
Three Component One-Pot Synthesis of Pyrido[2,3-d]pyrimidineDerivatives Catalyzed by KF-alumina |
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| WANG, Xiang-Shan,ZENG, Zhao-Sen,SHI, Da-Qing,TU, Shu-Jiang,WEI, Xian-Yong,ZONG, Zhi-Min. Three Component One-Pot Synthesis of Pyrido[2,3-d]pyrimidineDerivatives Catalyzed by KF-alumina[J]. Chinese Journal of Organic Chemistry, 2006, 26(2): 256-259 | |
| Authors: | WANG Xiang-Shan ZENG Zhao-Sen SHI Da-Qing TU Shu-Jiang WEI Xian-Yong ZONG Zhi-Min |
| Affiliation: | a School of Chemical Engineering, China University of Mining and Technology, Xuzhou 221008;b Department of Chemistry, Xuzhou Normal University, Xuzhou 221116;c Key Laboratory of Biotechnology on Medical Plant of Jiangsu Province, Xuzhou 221116 |
| Abstract: | A series of pyrido[2,3-d]pyrimidine derivatives were synthesized by the three component reaction of arylaldehyde, malononitrile and 4-amino-2,6-dihydroxylpyrimidine in ethyl alcohol at 80 ℃ catalyzed by KF-Al2O3. It was interesting that the further aromatization took place by air oxidation. Compared with other synthetic methods, this new method has the advantage of easier work-up, milder reaction conditions and good yields. The structure of the products was characterized by IR, 1H NMR spectra and elemental analysis. |
| Keywords: | pyrido[2 3-d]pyrimidine aromatization KF-Al2O3 synthesis |
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