Design and synthesis of biotinylated inositol phosphates relevant to the biotin-avidin techniques |
| |
Authors: | Anraku Kensaku Inoue Teruhiko Sugimoto Kenji Morii Takashi Mori Yasuo Okamoto Yoshinari Otsuka Masami |
| |
Affiliation: | Institute of Health Sciences, Kumamoto Health Science University, 325 Izumi-machi, Kumamoto 861-5598, Japan. |
| |
Abstract: | Six bifunctional molecules containing biotin and various inositol phosphates were synthesized. These compounds were designed on the basis of X-ray structures of the complexes of D-myo-inositol 1,4,5-triphosphates (IP(3)) and phospholipase C delta pleckstrin homology domain (PLCdelta PH) considering the application to the biotin-avidin techniques. The building blocks of the inositol moiety were synthesized starting with optically resolved myo-inositol derivatives and assembled to the biotin linker through a phosphate linkage. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|