A Green Blue LED-Driven Two-Liquid-Phase One-Pot Procedure for the Synthesis of Estrogen-Related Quinol Prodrugs |
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| Authors: | Elisa De Marchi Lorenzo Botta Bruno Mattia Bizzarri Raffaele Saladino |
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| Affiliation: | Department of Biological and Ecological Sciences, University of Tuscia, 01100 Viterbo, Italy |
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| Abstract: | Quinol derivatives of estrogens are effective pro-drugs in steroid replacement therapy. Here, we report that these compounds can be synthesized in one-pot conditions and high yield by blue LED-driven photo-oxygenation of parent estrogens. The oxidation was performed in buffer and eco-certified 2-methyltetrahydrofuran as the two-liquid-phase reaction solvent, and in the presence of meso-tetraphenyl porphyrin as the photosensitizer. Two steroidal prodrugs 10β, 17β-dihydroxyestra-1,4-dien-3-one (DHED) and 10β-Hydroxyestra-1,4-diene-3,17-dione (HEDD) were obtained with high yield and selectivity. |
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| Keywords: | estrogens estrogen-related quinols prodrug CNS-selective estrogen therapy DHED HEDD neuroprotection para-quinol photo-oxygenation photochemistry |
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