The effect of polymer architecture on the nano self-assemblies based on novel comb-shaped amphiphilic poly(allylamine) |
| |
| Authors: | Colin J Thompson Caixia Ding Xiaozhong Qu Zhenzhong Yang Ijeoma F Uchegbu Laurence Tetley Woei Ping Cheng |
| |
| Institution: | (1) School of Pharmacy and Life Sciences, The Robert Gordon University, Schoolhill, Aberdeen, AB10 1FR, UK;(2) State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China;(3) University of London, School of Pharmacy, 29-39 Brunswick Square, London, WC1N 1AX, UK;(4) Integrated Microscopy Facility, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK |
| |
| Abstract: | Twelve novel poly(allylamine) (PAA)-based, comb-shaped amphiphilic polymers have been developed. Hydrophobic groups of cetyl,
palmitoyl and cholesteryl were randomly grafted to PAA and quaternisation was carried out on some modified polymers. Polymers
were characterised using 1H NMR, elemental analysis and differential scanning calorimetry. All polymers formed nano self-assemblies in the aqueous solution
with a positive zeta potential and were able to encapsulate a hydrophobic agent, methyl orange, in the core. The critical
aggregation concentration (CAC) and the microviscosity were found to be dependent on the polymer hydrophobicity. Being the
most hydrophobic polymer, cholesteryl-grafted PAA had the lowest CAC (0.02 mg mL−1) and the highest microviscosity. They appeared to form dense nanoparticles and were transformed into novel nanostructures
in the presence of free cholesterol. Palmitoyl-grafted polymers formed nanoparticles while cetyl-grafted polymers formed polymeric
micelles. The flexibility of cetyl chains possibly resulted in the formation of multicore polymeric micelles. |
| |
| Keywords: | Self-assembly Nanoparticles Micelle Amphiphilic polymer |
| 本文献已被 SpringerLink 等数据库收录！ |
|
