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Magnetic microcapsules for targeted delivery of anticancer drugs
Authors:Tetsuro Kato  Ryosuke Nemoto  Hisashi Mori  Ryoetsu Abe  Katsuo Unno  Akio Goto  Hideyuki Murota  Masaoki Harada  Motofumi Homma
Affiliation:(1) Department of Urology, Akita University School of Medicine, 010 Akita, Japan;(2) Department of Urology, Pharmacy, Akita University School of Medicine, 010 Akita, Japan;(3) Department of Pathology, Akita University School of Medicine, 010 Akita, Japan;(4) Department of Materials Science, Faculty of Engineering, Tohoku University, 980 Sendai, Japan
Abstract:To achieve targeted distribution of anticancer drugs with sustained activity, ferromagnetic ethylcellulose microcapsules containing an anticancer drug, mitomycin C (FM-MMC-mc), were prepared by a method based on phase separation principles. Two prototypes of FM-MMC-mc were made: one with the drug as the core and zinc ferrite on its capsular surface (outer type); the other with both the drug and zinc ferrite as the core (inner type). Both preparations provided a sustained-release property and a sensitive response to conventional magnetic force, although certain differences in the release rate of drug, magnetic responsiveness, and particle size were found between the two dosage forms. Animal studies showed that the magnetic microcapsules could be magnetically controlled in the artery and urinary bladder. VX2 tumors in the rabbit hind limb and urinary bladder were successfully treated with magnetic control of FM-MMC-mc. Pharmacokinetic study revealed that the targeting of the microcapsules markedly enhanced the drug absorption into the surrounding tissues for a prolonged period of time. The results indicate the feasibility and effectiveness of the magnetic microcapsules as a targeted drug delivery system.
Keywords:Magnetic microcapsules, for anticancer drug delivery  zinc ferrite, in encapsulated anticancer drugs  targeting, of encapsulated anticancer drugs  artery, use of encapsulated anticancer drugs in  urinary bladder, use of encapsulated anticancer drugs in  VX2 tumor, use of encapsulated anticancer drugs against  anticancer drugs, use of encapsulated  magnetic microcapsules, use of anticancer drugs in
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