| N-硝基-2,4,6-三硝基苯基脲的合成及生物活性研究 |
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| 引用本文： | 江洪,崔燕,方利,陈长水. N-硝基-2,4,6-三硝基苯基脲的合成及生物活性研究[J]. 有机化学, 2007, 27(12): 1590-1593 |
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| 作者姓名： | 江洪 崔燕 方利 陈长水 |
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| 作者单位： | 1. 华中农业大学化学系,武汉,430070;华中农业大学化学生物研究所,武汉,430070
2. 华中农业大学化学系,武汉,430070 |
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| 基金项目： | 国家自然科学基金(No.39770845)，华中农业大学博士基金(No.52204-05047)资助项目. |
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| 摘 要： | 在甲苯溶液中，将N-硝基-2,4,6-三硝基苯胺与固体光气反应, 得到酰氯中间体, 该中间体无需分离, 然后直接与其它取代苯胺反应合成了13个未见文献报道的N-硝基-2,4,6-三硝基苯基脲类化合物, 其结构经1H NMR, IR, MS和元素分析确证. 初步测试结果表明: 当浓度为500 mg/L时, 部分化合物具有较好的抑制稗草生长活性.
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| 关 键 词： | N-硝基-2,4,6-三硝基苯基脲 N-硝基化合物 固体光气 除草活性 |
| 收稿时间： | 2007-01-10 |
| 修稿时间： | 2007-06-25 |
Synthesis and Biological Activity of N-Nitro-N-(2,4,6-trinitrophenyl) Urea |
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| JIANG,Hong,CUI,Yan,FANG,Li,CHENG,Chang-Shui. Synthesis and Biological Activity of N-Nitro-N-(2,4,6-trinitrophenyl) Urea[J]. Chinese Journal of Organic Chemistry, 2007, 27(12): 1590-1593 |
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| Authors: | JIANG Hong CUI Yan FANG Li CHENG Chang-Shui |
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| Affiliation: | ( Department of Chemistey, Huazhong Agricultural University, Wuhan 430070)( Institute of Chemical Biology, Huazhong Agricultural University, Wuhan 430070) |
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| Abstract: | N-Nitro-2,4,6-trinitroaniline reacted with bis(trichloromethyl) carbonate in toluene produced car-bamoyl chloride. Treatment of the chloride, without any further purification, with substituted anilines gave thirteen novel N-nitro-N-(2,4,6-trinitrophenyl) urea derivatives. Their structures were confirmed by 1H NMR, IR, MS spectra and elemental analysis. Preliminary biological tests show that some of these target compounds have good herbicidal activities against Echinochloa crusgalli beauv L at the concentration of 500 mg/L. |
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| Keywords: | N-nitro-N-(2 4 6-trinitrophenyl) urea nitramide bis(trichloromethyl) carbonate herbicidal ac-tivity |
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