Palladium-catalyzed amination in the synthesis of macrocycles comprising cholane, polyamine and pyridine units |
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| Authors: | Alexei D. Averin Elena R. Ranyuk Svetlana L. Golub Irina P. Beletskaya |
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| Affiliation: | a Lomonosov Moscow State University, Department of Chemistry, Leninskie Gory, Moscow 119992, Russia
b A. N. Frumkin Institute of Physical and Electrochemistry, 31 Leninskii Prosp., Moscow 119991, Russia |
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| Abstract: | 3,24-Bis(6-chloropyridin-2-yloxy)cholane, obtained from 3,24-cholandiol via a Mitsunobu reaction, was successfully used for the synthesis of a variety of polyazamacrocycles using Pd-catalyzed amination reaction with linear polyamines. The competing formation of cyclodimers and other cyclic oligomers was found to be strongly dependent on the nature of the polyamines employed. |
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