A facile and one-pot synthesis of <em>N</em>-Fmoc/Bsmoc/Boc/Z-protected ureidopeptides and peptidyl ureas employing diphenylphosphoryl azide [DPPA]期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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A facile and one-pot synthesis of N-Fmoc/Bsmoc/Boc/Z-protected ureidopeptides and peptidyl ureas employing diphenylphosphoryl azide [DPPA]

Authors:	Vommina V Sureshbabu G Chennakrishnareddy N Narendra

Institution:	Peptide Research Laboratory, Department of Studies in Chemistry, Central College Campus, Dr. B. R. Ambedkar Veedhi, Bangalore University, Bangalore 560 001, India

Abstract:	Diphenylphosphoryl azide (DPPA) mediated one-pot synthesis of N^α-Fmoc/Bsmoc/Boc/Z-protected ureidopeptides and peptidyl ureas as well as phenyl/succinimidyl (N^α-urethane protected) methyl carbamates starting from N^α-protected amino acids is reported. The formation of an azide, its rearrangement and coupling with an amino component is accomplished in a sequence of one-pot operations. The protocol has incorporated urea linkages in a sterically hindered peptide.

Keywords:	Diphenylphosphoryl azide Ureidopeptides Peptidyl ureas Curtius rearrangement One-pot synthesis
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