| 膜表面具有2-羟基-3-氯丙基或环氧丙基的对pH和离子强度敏感的新型磷酸酯囊泡 |
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| 引用本文： | 宋溪明,张国林,吴秋华,刘凤岐,田鹏,刘振荣,张向东,张锋,王君,刘祁涛.膜表面具有2-羟基-3-氯丙基或环氧丙基的对pH和离子强度敏感的新型磷酸酯囊泡[J].高等学校化学学报,2004,25(4):787-789. |
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| 作者姓名： | 宋溪明 张国林 吴秋华 刘凤岐 田鹏 刘振荣 张向东 张锋 王君 刘祁涛 |
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| 作者单位： | 1. 辽宁大学化学科学与工程学院, 沈阳 110036;
2. 北京大学化学与分子工程学院, 北京 100871;
3. 吉林大学化学学院, 长春 130023 |
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| 基金项目： | 国家自然科学基金 (批准号 :2 95 710 15 )，辽宁省青年科技人才培养基金 (批准号 :973 0 0 7)资助 |
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| 摘 要： | 近年来，囊泡已被广泛应用于药物基因传导、人工模拟酶和纳米分子器件等研究领域，在对囊泡研究中，需要对囊泡进行某种包结或化学修饰，并对囊泡的稳定性及对物质的包结与释放进行可控操作．囊泡状态下使囊泡分子间聚合是提高囊泡稳定性的有效方法之一，苯乙烯等一些可进行聚合反应的基团已被导入囊泡中，我们曾在单长链烷基磷酸酯的亲水头部引入2-羟基3-氯丙基，进而将其转变成化学活性的环氧丙基.
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| 关 键 词： | 泡囊 磷酸酯 2-羟基-3-氯丙基 环氧基 |
| 文章编号： | 0251-0790(2004)04-0787-03 |
| 收稿时间： | 2003-03-20 |
Novel pH and Ionic Strength-sensitive Vesicles Composed of Alkyl Phosphates with 2-Hydroxy-3-chloropropyl or Epoxy Propyl on Their Membrane Surface |
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| SONG Xi-Ming ,ZHANG Guo-Lin ,WU Qiu-Hua ,LIU Feng-Qi ,TIAN Peng ,LIU Zhen-Rong ,ZHANG Xiang-Dong ,ZHANG Feng ,WANG Jun ,LIU Qi-Tao.Novel pH and Ionic Strength-sensitive Vesicles Composed of Alkyl Phosphates with 2-Hydroxy-3-chloropropyl or Epoxy Propyl on Their Membrane Surface[J].Chemical Research In Chinese Universities,2004,25(4):787-789. |
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| Authors: | SONG Xi-Ming ZHANG Guo-Lin WU Qiu-Hua LIU Feng-Qi TIAN Peng LIU Zhen-Rong ZHANG Xiang-Dong ZHANG Feng WANG Jun LIU Qi-Tao |
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| Institution: | 1. School of Chemical Science and Engineering, Liaoning University, Shenyang 110036, China;
2. College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China;
3. College of Chemistry, Jilin University, Changchun 130023, China |
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| Abstract: | Amphiphilic alkyl (dodecyl and hexadecyl)-2-hydroxy-3-chloropropyl phosphates (C12 - and C16 -AHCP) were synthesized, and then alkyl glycidyl phosphates (C12 - and C16 -AGP) were quantitatively obtained by the treatment of AHCP with NaOH in order to prepare a novel vesicle which has reactive and polymerizable epoxy group on its membrane surface. The bilayer vesicles were formed by ultrasonication of aqueous dispersion of C16 -AHCP or C16 -AGP, but the vesicles composed of C12 -AHCP and C12 -AGP were not obtained by the same treatment. Both of C16 -AHCP and C16 -AGP bilayer vesicles are only stable at pH5—10 or the ionic strength below 0.15. The gel-filtration chromatography and the UV-Vis absorption spectroscopic studies on Co(Ⅱ) tetrakis(propyloxycarbonyl)phthalocyanine as a lipophilic probe indicated that the phthalocyanine was effectively incorporated into the C16 -AHCP bilayer membranes and predominantly present in a monomeric state in the membranes, which is much different from its leading diameric state in SDS micelle and ethanol. |
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| Keywords: | Vesicle Phosphate 2-Hydroxy-3-chloropropyl Epoxy |
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