Cholesterol–phospholipid interactions, the liquid-ordered phase and lipid rafts in model and biological membranes |
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Authors: | Todd P W McMullen Ruthven N A H Lewis Ronald N McElhaney |
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Institution: | Department of Biochemistry, University of Alberta, Edmonton, AB, Canada T6G 2H7 |
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Abstract: | The existence of relatively large and long-lived detergent-insoluble, sphingolipid- and cholesterol-enriched, liquid-ordered lipid raft domains in the plasma membranes of eukaryotic cells has become widely accepted. However, we believe that the evidence for their existence is not compelling despite extensive work on both lipid bilayer model and biological membranes. We review here the results of recent studies, which in our view call into question the existence of lipid rafts in membranes, at least in the form commonly depicted. |
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Keywords: | Cholesterol– phospholipid interactions Liquid-ordered phase and lipid rafts Model and biological membranes |
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