Continuous-flow synthesis of monoarylated acetaldehydes using aryldiazonium salts |
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Authors: | Natalia Chernyak Stephen L Buchwald |
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Affiliation: | Department of Chemistry, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States. |
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Abstract: | Anilines and ethyl vinyl ether can be used as precursors for a process that is the synthetic equivalent of the α-arylation of acetaldehyde enolate. The reaction manifests a high level of functional group compatibility, allowing the ready preparation of a number of synthetically valuable compounds. |
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