Screening organophosphorus nerve agent degradation products in pesticide mixtures by GC-ICPMS |
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Authors: | Douglas D Richardson Joseph A Caruso |
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Institution: | (1) Department of Chemistry, McMicken College of Arts and Sciences, University of Cincinnati, Cincinnati, OH 45221-0172, USA |
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Abstract: | Gas chromatography inductively coupled plasma mass spectrometry (GC-ICPMS) was utilized for the analysis of four organophosphorus
nerve agent degradation products in the presence of mixtures of common organophosphorus pesticides. The first degradation
products of sarin (isopropyl methylphosphonic acid, GB acid), cyclosarin (cyclohexyl methylphosphonic acid, GF acid), and
soman (pinacolyl methylphosphonic acid) as well as their common final hydrolysis product methyl phosphonic acid were utilized
throughout these experiments. Due to the non-volatile nature of these alkyl phosphonic acid degradation products, derivatization
was performed to generate the volatile tert-butyl dimethylsilyl species. Degraded organophosphorus pesticide standards were obtained for acephate, chlorpyrifos, dichlorvos,
ethion, and parathion ethyl. Mixtures consisting of three pesticides in the presence of a single nerve agent degradation product
were prepared. GC-ICPMS allowed for the separation and detection of all four degradation products in the presence of pesticide
mixtures in just over 12 minutes. This is the first study analyzing pesticides as interfering species for analysis of nerve
agent degradation products by GC-ICPMS. |
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Keywords: | GC Mass spectrometry ICP-MS Pesticides Endocrine disruptors Speciation |
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