Bioanalytical applications of 'fast chromatography' to high-throughput liquid chromatography/tandem mass spectrometric quantitation |
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| Authors: | Romanyshyn L Tiller P R Hop C E |
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| Institution: | Drug Metabolism, Merck Research Laboratories, RY80L-109, P.O. Box 2000, Rahway, NJ 07065-0900, USA. leslie_romanyshyn@merck.com |
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| Abstract: | A fast chromatographic separation approach that enables rapid method development for high-throughput sample quantification is discussed. This approach has been used to analyze samples from various biological matrices. Data are presented from in vivo pharmacokinetic studies (plasma) and in vitro drug metabolism and transport studies (hepatic microsomes, hepatocytes, and Caco-2 cells). |
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