Encapsulation and selective recognition of molecularly imprinted theophylline and 17beta-estradiol nanoparticles within electrospun polymer nanofibers |
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Authors: | Chronakis Ioannis S Jakob Alexandra Hagström Bengt Ye Lei |
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Institution: | IFP Research, Swedish Institute for Fiber and Polymer Research, Box 104, SE 431 22 M?lndal, Sweden. ioannis.chronakis@ifp.se |
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Abstract: | Molecularly imprinted nanoparticles are cross-linked polymer colloids containing tailor-made molecular recognition sites. In this study, molecularly imprinted nanoparticles were easily encapsulated within polymer nanofibers using an electrospinning technique to produce a new type of molecular recognition material. Poly(ethylene terephthalate) (PET) was used as the supporting nanofibers matrix to encapsulate theophylline and 17beta-estradiol imprinted nanoparticles. The composite nanofibers had an average diameter of 150-300 nm, depending on the content of molecularly imprinted nanoparticles. For the theophylline and 17beta-estradiol imprinted polymers, an optimal loading of molecularly imprinted nanoparticles was 25-37.5 wt % based on PET. The composite nanofibers prepared under these conditions had a well-defined morphology and displayed the best selective target recognition. Our approach of electrospinning-for-molecularly imprinted nanoparticles-encapsulation has unique advantages and opens new application opportunities for molecularly imprinted nanoparticles and electrospun nanofibers. |
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