Total synthesis of (-)-aspidospermine via diastereoselective ring-closing olefin metathesis |
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| Authors: | Fukuda Yu-Ichi Shindo Mitsuru Shishido Kozo |
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| Institution: | Institute for Medicinal Resources, University of Tokushima, 1-78 Sho-machi, Tokushima 770-8505, Japan. |
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| Abstract: | An enantiocontrolled total synthesis of (-)-aspidospermine has been achieved. The key element of the strategy is the diastereoselective construction of the quaternary stereogenic center employing 1,4-asymmetric induction during the ring-closing olefin metathesis. |
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