Extensively stereodiversified scaffolds for use in diversity-oriented library synthesis |
| |
| Authors: | Gierasch Tiffany Malinky Shi Zhangjie Verdine Gregory L |
| |
| Affiliation: | Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA. |
| |
| Abstract: | The syntheses of stereodiverse libraries of 12 and 19 are reported, where each asterisk represents an independently varied stereocenter. These scaffolds provide additional templates for investigations of geometric diversity in library syntheses. Libraries of these N-Fmoc-amino acids were further functionalized by incorporation into a peptide sequence, demonstrating the utility of 12 and 19 as building blocks for diversity oriented synthesis. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
