Acylation and bromination of some 2-mercaptothieno[2,3-d]pyrimidinones and synthesis of their 2-amino derivatives

The acylation of 2-thio-3-R-4-oxo-3,4-dihydrothieno2,3-d]-pyrimidines by means of benzoyl chloride was studied. Depending on the reaction conditions, it may take place with the formation of S-substituted and N-substituted derivatives. The bromination of the sodium salts of thienopyrimidines and their S- and N-substituted derivatives is accompanied by the formation of disulfides, which do not react with electrophilic reagents but react with amines to give 2-amino derivatives of thienopyrimidines.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1333–1336, October, 1985.