Recognition of CG inversions in DNA triple helices by methylated 3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues |
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| Authors: | Ranasinghe Rohan T Rusling David A Powers Vicki E C Fox Keith R Brown Tom |
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| Institution: | School of Chemistry, University of Southampton, Highfield, Southampton, UK SO17 1BJ. |
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| Abstract: | Substituted 3H-pyrrolo2,3-d]pyrimidin-2(7H)-one nucleoside analogues have been synthesised from 5-alkynyl-uridine derivatives, incorporated into triplex forming oligonucleotides (TFOs) and found to selectively bind CG inversions with enhanced affinity compared to T. |
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