A facile synthesis of pyridazinone derivatives under ultrasonic irradiation |
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| Authors: | Dorina Mantu Costel Moldoveanu Alina Nicolescu Calin Deleanu Ionel I. Mangalagiu |
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| Affiliation: | 1. “Al. I. Cuza” University of Iasi, Organic and Biochemistry Department, Bd. Carol 11, 700506 Iasi, Romania;2. P. Poni” Institute of Macromolecular Chemistry, Aleea Grigore Ghica Voda 41-A, RO-700487 Iasi, Romania |
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| Abstract: | A new, efficient and general method for preparation of N-substituted-pyridazinones using ultrasound irradiation is reported. Under ultrasound the reaction time decreases substantially, the yields are high and the reaction conditions are mild. It was noticed that substituents at the 3-(6)-position of pyridazone heterocycle have a substantial influence on the reactivity, while the effect of the substituents at the 1-(2)-position seems to be of minor importance. A comparative study of the reactions performed under ultrasound conditions versus at room temperature has been done. |
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