Ultrasound assisted reactions of steroid analogous of anticipated biological activities |
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| Authors: | Vasilichia Bejan Costel Moldoveanu Ionel I Mangalagiu |
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| Institution: | Al. I. Cuza University of Iasi, Organic and Biochemistry Department, Bd. Carol 11, 700506 Iasi, Romania |
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| Abstract: | A new, fast, efficient and general method for preparation of steroid analogous of anticipated biological activity under ultrasound irradiation and classical heating is reported. The reaction pathway involves two steps: quaternization of phthalazine heterocycle followed by a 3+2 dipolar cycloaddition of cycloimmonium ylides to dienophiles. Under ultrasound the reaction time decreases substantially, the yields are higher, the reaction conditions are milder. A comparative study ultrasound verses classical heating has been done. |
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