Real-time monitoring of ethane in human breath using mid-infrared cavity leak-out spectroscopy |
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Authors: | H Dahnke D Kleine P Hering M Mürtz |
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Institution: | Institut für Lasermedizin, Universit?t Düsseldorf, 40225 Düsseldorf, Germany, DE
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Abstract: | We report on spectroscopic real-time analysis of ethane traces in exhaled human breath. Ethane is considered the most important
volatile marker of free-radical induced lipid peroxidation and cell damage in the human body. Our measurements were carried
out by means of mid-infrared cavity leak-out spectroscopy in the 3 μm region, a cw variant of cavity ring-down spectroscopy.
The spectrometer is based on a CO overtone laser with tunable microwave sidebands. The resulting system proved to be an unique
tool with high sensitivity and selectivity for rapid and precise breath testing. With a 5 s integration time, we achieved
a detection limit on the order of 100 parts per trillion ethane in human breath. Thus, sample preconcentration is unnecessary.
Time-resolved monitoring of the decaying ethane fraction in breath after smoking a cigarette is demonstrated.
Received: 13 March 2001 / Published online: 9 May 2001 |
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Keywords: | PACS: 07 88 +y 42 62 Fi 07 57 Ty |
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