Technological
quality determination of pharmaceutical disintegrant by DSC cooling and DSC
photovisual |
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| Authors: | Ana C D Medeiros Lidiane P Correia Mônica O da S Simões R O Macêdo |
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| Institution: | 1.Unified Laboratory
of Medicine Development and Assay (LUDEM), Pharmacy Department,Federal University of Paraíba,Jo?o
Pessoa,Brazil;2.Pharmacy Department,Stadual University
of Paraíba,Campina Grande,Brazil |
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| Abstract: | A number of disintegrants
are available on the market. They improve tablets’ disintegration. The
objective of this work is the comparison of the technological quality parameters
of disintegrants using different analytical techniques. Three batches of disintegrants
and their binary mixtures (water:disintegrants) were investigated. Cooling
experiments were used from –30 up to 200°C. The data obtained showed
calorimetric differences between the samples. In the binary mixtures water
showed different crystallization behaviour from the one found in the literature.
According to the results DSC technique helped the quality control of different
disintegrants. |
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| Keywords: | crystallization water disintegrants DSC cooling DSC photovisual and particles size |
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