Polyelectrolyte complex nanoparticles from chitosan and poly(acrylic acid) and Polystyrene‐block‐poly(acrylic acid) |
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| Authors: | Julien Rolland Pierre Guillet Jean‐Marc Schumers Nicolas Duhem Véronique Préat Jean‐François Gohy |
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| Affiliation: | 1. Institute of Condensed Matter and Nanosciences (IMCN), Bio‐ and Soft Matter (BSMA), Université catholique de Louvain, Place L. Pasteur 1, 1348 Louvain‐la‐Neuve, Belgium;2. Institut des Biomolécules Max‐Mousseron (IBMM), Université d'Avignon et des Pays de Vaucluse, Equipe Chimie Bioorganique et Systèmes Amphiphiles, 33 rue Louis Pasteur 84000 Avignon, France;3. Louvain Drug Research Institute (LDRI), Pharmaceutics and Drug Delivery (FARG), Université catholique de Louvain, Avenue Mounier 73, 1200 Brussels, Belgium |
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| Abstract: | Interpolymer polyelectrolyte complexes of chitosan (CS) with poly(acrylic acid) homopolymers and polystyrene‐block‐poly(acrylic acid) diblock copolymers were prepared and characterized. The influence of the positive/negative charge balance (charge ratio), pH, and ionic strength were thoroughly studied by dynamic light scattering. The existence of a strong polyelectrolyte effect was also highlighted in this study. Domains of stability, in which nanoparticle sizes are smaller than 100 and 200 nm for complexes of CS with the homopolymer and copolymer, respectively, were identified and confirmed by scanning electron microscopy and atomic force microscopy. The charged nature of the surface of the nanoparticles was evidenced by Zeta potential measurements. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012 |
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| Keywords: | biopolymers chitosan dynamic light scattering nanoparticles polyelectrolytes |
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