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Organometallic derivatives of penicillins and cephalosporins a new class of semi-synthetic antibiotics |
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| Authors: | Eve I Edwards Roger Epton George Marr |
| Institution: | Department of Physical Sciences, The Polytechnic Wolverh, mpton, WV1 1LY Great Britain |
| Abstract: | Novel semi-synthetic derivatives of penicillin and cephalosporin have been prepared in which the conventional phenyl or heteroaromatic group has been replaced by a ferrocene moiety, and in which the metal atom is in close proximity to the β-lactam ring of the antibiotic; several of the compounds exhibit high antibiotic activity and others are potent β-lactamase inhibitors. |
| Keywords: | Author to whom correspondence should be addressed present address Building Research Establishment Garston Watford WD2 7JR Herts (Great Britain) |
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