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Methodology for the qualitative screening of parallel arrays of potential Am ligands using a photographic film |
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| Authors: | Henk H. Dam David N. Reinhoudt |
| Affiliation: | a Laboratory of Molecular Nanofabrication, Mesa+ Research Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands b Laboratory of Supramolecular Chemistry and Technology, Mesa+ Research Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands c Nuclear Research and Consultancy Group, Radiation and Environment, P.O. Box 25, 1755 ZG Petten, The Netherlands |
| Abstract: | A screening method for parallel Am3+ ligand libraries is presented. The method makes use of α-radiation in combination with a photographic film to detect the complexed Am3+. After screening and development of the film spots of varying intensities are obtained. The intensities of the spots correspond with the amount of complexed Am3+. This allows a fast discrimination between the Am3+ complexation efficiencies of ligands from large libraries. Depending on the exposure time of the film, activities as small as 5 Bq 241Am can be detected. Using internal standards a semi-quantitative assessment can be performed. |
| Keywords: | Actinides Am3+ ligand Combinatorial Library screening Photographic film |
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