Efficient and green microwave-assisted one-pot synthesis of azaindolizines in PEG-400 and water |
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| Authors: | Devendra S. Wagare Mazhar Farooqui Tushar D. Keche Ayesha Durrani |
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| Affiliation: | 1. Department of Chemistry, Vivekanand College, Aurangabad, Indiadswagare@gmail.com;3. Department of Chemistry, Dr. Rafique Zakaria College for Women, Aurangabad, India;4. Department of Chemistry, Vivekanand College, Aurangabad, India |
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| Abstract: | A facile, convenient, environmentally benign, and one-pot synthesis of imidazo[1,2-a]pyridines from 2-aminopyridines and in-situ generated phenacyl bromides under microwave irradiation in polyethylene glycol (PEG-400) and water (1:2) has been developed. The protocol provides a better alternative to the existing method as it involves utilization of in-situ-generated α-bromoacetophenones, avoids the use of lachrymatric α-haloketones as well as volatile toxic organic solvents, and reduces the reaction time to obtain excellent yield. |
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| Keywords: | 2-Aminopyridines imidazo[1,2-a]pyridines microwave irradiation NBS PEG-400–water |
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