Synthesis,crystal structures,and DNA-binding studies of two silver(I) complexes with 1,3-bis(1-ethylbenzimidazol-2-yl)-2-thiapropane |
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Authors: | Yuling Xu Han Zhang Stephen Opeyemi Aderinto Zaihui Yang |
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Affiliation: | School of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou, PR China |
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Abstract: | Two new silver(I) complexes, [Ag(bebt)(methacrylate)] (1) and [Ag2(bebt)2](pic)2 (2) (bebt = 1,3-bis(1-ethylbenzimidazol-2-yl)-2-thiapropane, pic = picrate), have been synthesized and characterized by physico-chemical and spectroscopic methods. Single-crystal X-ray diffraction revealed that the structure of 1 was four-coordinate in a distorted tetrahedral geometry, while in 2, it may be described as a 2 + 1 coordinated silver(I) compound with a nearly linear N–Ag–N backbone and a weak Ag–S interaction. Two ligands are arranged in a face-to-face syn conformation to coordinate to two Ag(I) ions from opposite directions in 2, generating a U-type double layer structure around the metal ions. Experimental studies of the DNA-binding properties indicated that free bebt and both complexes bind to DNA via intercalation, and the order of the binding affinity is 2 > 1 > bebt. |
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Keywords: | Benzimidazole silver(I) complex crystal structure DNA-binding property synthesis |
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