Copper complexes with a flexible piperazinyl arm: nuclearity driven catecholase activity and interactions with biomolecules |
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| Authors: | Mriganka Das Poulami Mandal Novina Malviya Indrani Choudhuri Maria Adilia Januário Charmier Susana Morgado |
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| Institution: | 1. Department of Chemistry, School of Basic Sciences, Indian Institute of Technology Indore, Indore, India;2. Faculty of Engineering, Universidade Lusófona, Lisbon, Portugal;3. CQE, Instituto Superior Técnico-Universidade de Lisboa (IST-UL), Lisbon, Portugal |
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| Abstract: | Three new Cu(II) complexes, Cu(HL1)(pyridine)(H2O)](ClO4)2·2MeOH (1), Cu2(HL1)2(NO3)2](NO3)2·3H2O (2) and Cu(HL2)(NO3)2]·MeCN (3), have been synthesized from two Schiff base ligands HL1 = 1-phenyl-3-((2-(piperazin-4-yl)ethyl)imino)but-1-en-1-ol and HL2 = 4-((2-(piperazin-1-yl)ethyl)imino)pent-2-en-2-ol] using the chair conformer of a flexible piperazinyl moiety. Structural analysis reveals that 1 and 3 are monomeric Cu(II) complexes consisting of five- and six-coordinate Cu(II), respectively, whereas 2 is a dinuclear Cu(II) complex consisting of two different Cu(II) centers, one square planar with the other distorted octahedral. Screening tests were conducted to quantify the binding of 1–3 towards DNA and BSA as well as the DNA cleavage activity of these complexes using gel electrophoresis. Enzyme kinetic studies were also performed for the complexes mimicking catecholase-like activities. Antibacterial activities of these complexes were also examined towards Methicillin-Resistant Staphylococcus aureus bacteria. The results reflect that 2 is more active than the monomeric complexes, which is further corroborated by density functional theory study. |
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| Keywords: | Cu(II) complexes with crystal structure DNA binding cleavage and BSA binding catecholase like activity antimicrobial activity computational study |
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