Sequential change in one-pot,three-component protocol: A stepping stone in heterocyclic synthesis |
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| Authors: | Ranganathan Raja Dinesh Murugan Archana Sivasubramaniyan Jaabil George Sakthivel Perumal |
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| Institution: | Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, India |
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| Abstract: | Two different heterocycles, thiazole-2-imines and imidazole-2-thiones, have been conveniently synthesized by just altering the sequential order (1 + 2 + 3 or 1 + 3 + 2) when combining the same components aryl amine (1), aryl isothiocyanate (2), and phenacyl bromide (3)] in one-pot, three-component protocols. The third possible sequential order of combination (2 + 3 + 1) chemoselectively affords thiazole-2-imine. The finding is a stepping stone in the synthetic applicability of sequential one-pot, three-component protocols. |
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| Keywords: | Imidazole-2-thione one pot sequential change stepping stone thiazole-2-imine three components |
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