Synthesis and investigation of antimicrobial activity of compounds derived from benzo[C][1,2,5]oxadiazole-1-oxides and phenolates |
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| Authors: | Elena A Chugunova Nurgali I Akylbekov Alexandra D Voloshina Natalia V Kulik Vladimir V Zobov Vasily M Babaev |
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| Institution: | 1. A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences, Kazan, Russiachugunova.e.a@gmail.com;3. Kazan National Research Technological University, Kazan, Russia;4. A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences, Kazan, Russia |
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| Abstract: | (Di)chloro(di)nitrobenzofuroxans form substitution products involving carbon atoms with phenolates in isopropyl alcohol medium. In the case of 4,6-dinitro-5,7-dichlorobenzofuroxan, besides replacement of one chlorine atom and the formation of C-bonded product, we observed the hydrolysis of the second chlorine and replacement of it by hydroxyl group. Products of reaction of 4,6-dichloro-5-nitrobenzofuroxan with phenolates display excellent antimicrobial activity and have dual action, both against bacteria and fungi. |
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| Keywords: | Antimicrobial activity benzofuroxan C-bonded product dual action phenolates |
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