Synthesis,crystal structure,and Helicobacter pylori urease inhibition of a dicyanoamide bridged Cu(I/II) complex |
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| Authors: | Yueyang Zhu Cun-Fang Wang Kai Yan Ke-Dong Zhao Gui-Hua Sheng Qiqige Hu |
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| Institution: | 1. Department of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, PR China;2. School of Life Sciences, Shandong University of Technology, Zibo, PR China |
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| Abstract: | A dicyanoamide-bridged polymeric copper(I/II) complex, CuII(sal)(bipy)CuI(dca)2]n, was prepared by reaction of 5-methylchlorosalicylaldehyde (Hsal), 2,2′-bipyridine (bipy), sodium dicyanoamide (Nadca), and copper perchlorate in methanol. The complex was characterized by elemental analyses, infrared and electronic spectroscopy, and single-crystal X-ray determination. CuII has a square pyramidal coordination, and CuI has triangular coordination. The complex showed high urease inhibitory activity with IC50 value of 0.16 ± 0.23 μM. |
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| Keywords: | Copper complex 5-methylsalicylaldehyde 2 2′-bipyridine crystal structure urease inhibition |
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