Ultrasound-assisted synthesis of diversely functionalized tetrahydro-1H-Indole-4(5H)-one using Brønsted base silica sodium carbonate (SSC) as a catalyst under solvent-free conditions |
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| Authors: | Vijay Vilas Shinde Seung Min Lee Jeong Su Oh Kwon Taek Lim |
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| Institution: | 1. Department of Image Science and Engineering, Pukyong National University, Busan, Republic of Korea;2. LED Convergence Engineering Department, Specialized Graduate School Science and Technology Convergence, Pukyong National University, Busan, Republic of Korea |
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| Abstract: | An ultrasound-promoted, environmentally benign, efficient procedure has been developed for the synthesis of biologically active tetrahydro-1H-indol-4(5H)-one using heterogeneous Brønsted base silica sodium carbonate (SSC) as a catalyst under solvent-free conditions. In comparison to the conventional methods, this efficient green protocol provides remarkable advantages such as good to excellent yields, shorter reaction time, low cost, and easy workup procedure and bypasses the use of hazardous transition-metal catalysts and organic solvents. |
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| Keywords: | Brønsted base silica sodium carbonate (SSC) solvent-free tetrahydro-1H-indol-4(5H)-one ultrasound |
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