Chiral phosphine-phosphoramidite ligands in asymmetric catalysis |
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| Authors: | Xiu-Shuai Chen |
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| Affiliation: | 1. School of Light Industry and Chemical Enginerring, Dalian Polytechnic University, Dalian, China;2. Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China |
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| Abstract: | Chiral phosphine-phosphoramidite ligands, featuring ready availability, easy modification, and stability towards air and moisture, have recently emerged as a new kind of robust ligands for asymmetric catalysis. They have been found to display wide utilities in various catalytic asymmetric reactions, giving excellent enantioselectivities in the Rh-, Ru-, and Ir-catalyzed asymmetric hydrogenation of C?C, C?O, and C?N double bonds; Rh-catalyzed asymmetric hydroformylation; Pd-catalyzed asymmetric hydrophosphorylation; Pd-catalyzed asymmetric allylic alkylation; Ag-catalyzed asymmetric [3 + 2] cycloaddition; and Cu-catalyzed conjugate addition and reduction. In this review, the progress on the development of chiral phosphine-phosphoramidite ligands in asymmetric catalysis has been summarized. |
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| Keywords: | Asymmetric catalysis chiral ligand hydroformylation hydrogenation phosphine-phosphoramidite |
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