Recent developments in the chemistry of bicyclic 6-6 systems: Chemistry of pyrido[1,2-c]pyrimidines |
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Authors: | Khaled M Elattar Ramy Rabie Mohamed M Hammouda |
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Institution: | 1. Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egyptkhaledelattar2@yahoo.com;3. Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt;4. Mansoura Fevers Hospital Chemistry Laboratory, Mansoura, Egypt |
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Abstract: | The present review provides a study on the structural features, reactions, and synthetic methodologies of pyrido1,2-c]pyrimidines. The maximum deviation from the mean plane of the pyridopyrimidine skeleton of 4-(pyridin-2-yl)-1H-pyrido1,2-c]pyrimidine-1,3(2H)-dione indicated a reasonably planar system. The aim of this review is to give an overview of the diverse methodologies that have been reported on the chemistry of pyrido1,2-c]pyrimidines. The different synthetic routes have been grouped according to the way the pyrido1,2-c]pyrimidine moiety has been created. Thus, pyrido1,2-c]pyrimidine compounds were obtained by the formation of one bond α to the bridgehead nitrogen atom 6+0(β)] and formation of two bonds from (3+3], 4+2], and 5+1]) atom fragments. The mechanistic pathways of the reactions are discussed. |
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Keywords: | Chemical structure studies pyrido[1 2-c]pyrimidines reactions and synthetic applications spectroscopy |
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