Copper-catalyzed one-pot process to construct triazole-linked urea derivatives |
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| Authors: | Kung-Kai Kuo Siva Senthil Kumar Boominathan Jaya Kishore Vandavasi Jia-Shing Hsiao Jeh-Jeng Wang |
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| Institution: | 1. Department of Surgery, School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;2. Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, Taiwan |
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| Abstract: | A new one-pot synthetic methodology has been developed to construct the triazole-linked urea derivatives. In the same step, triazole forms from azide and alkyne via click reaction and urea forms from addition reaction of amines and isocyanates. The notable features of this work include wide substrate scope, atom economy, environmental friendliness, and easily accessible starting materials. The preliminary biological screening of synthesized compounds show promising cytotoxic activity in basal cell carcinoma (BCC) cell lines. |
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| Keywords: | BCC cell lines copper catalysis one-pot reaction triazoles urea |
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