Stereoselective total synthesis of sporiolide B and attempted synthesis of sporiolide A |
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| Authors: | Gattu Sridhar Gangavaram V M Sharma |
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| Institution: | 1. Organic and Biomolecular Chemistry Division, CSIR Indian Institute of Chemical Technology, Hyderabad, Indiasridhar1org@yahoo.com;3. Organic and Biomolecular Chemistry Division, CSIR Indian Institute of Chemical Technology, Hyderabad, India |
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| Abstract: | A simple and efficient stereoselective total synthesis of sporiolide B and attempted synthesis of sporiolide A, from epichlorohydrin, using asymmetric synthetic approach is reported. The key reactions involved are Sharpless epoxidation, Jacobsen reaction, syn-allylation, Yamaguchi esterification, and Grubbs ring-closing metatheses reaction to result in the macrocyclic ring system. |
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| Keywords: | Ring-closing metathesis syn-allylation sporiolide A sporiolide B Yamaguchi esterification |
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