Silver(I) complexes with halo-substituted cyanoanilines: synthesis,characterization and antibacterial activity |
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| Authors: | Wei Qian Hao-Kun Yuan Ran Zhang |
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| Affiliation: | 1. School of Life Sciences, Sichuan Normal University, Chengdu, PR China;2. School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, PR China |
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| Abstract: | Four Ag(I) complexes, [Ag(L1)2](NO3) (1), [Ag(L2)(NO3)] (2), [Ag(L3)3](NO3) (3), and [Ag(L4)2](NO3) (4), with ligands derived from halo-containing cyanoanilines (L1 = 4-amino-3fluorobenzonitrile, L2 = 4-amino-3-chlorobenzonitrile, L3 = 4-amino-3-bromobenzonitrile, L4 = 4-amino-2-bromobenzonitrile) were synthesized and characterized by C, H, and N elemental analysis, IR and 1H NMR spectroscopy and single crystal X-ray diffraction. Complexes 1–4 crystallized in the triclinic space group C2/c, P2(1)/n, P-1 and C2/c, respectively. In 1 and 4, Ag+ is four-coordinate with L1 or L4 to form 1-D ∞{[Ag(L1/L4)2]+} polymeric cations. In 2, Ag+ is three-coordinate by two L2 ligands and one NO3? ligand to form a 1-D ∞{[Ag(L2)(NO3)]} zigzag chain. In 3, Ag+ is four-coordinate by L3 to form a dinuclear [Ag(L3)3]+ cation. The NO3? is a 4-connector bridging group in 1 and 3 and a 5-connector bridging group in 2 and 4. The intermolecular hydrogen bonds and Ag?O weak interactions play important roles in forming 3-D networks of 1–4. The antibacterial activities for 1–4 were evaluated against Bacillus subtilis, Staphylococcus aureus and Escherichia coli with MTT method. The antibacterial results indicated that 2 showed the best inhibitory activity against the test bacterial strains, and was as potent as chloramphenicol. |
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| Keywords: | Halo-substituted cyanoaniline silver complexes crystal structure antibacterial activities |
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