One-pot synthesis of oxoisoindoline-1,2,3-triazole hybrid by a Ugi–click reaction |
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| Authors: | Sara Akrami Loghman Firoozpour Fereshteh Goli-Garmroodi Setareh Moghimi Mohammad Mahdavi Afsaneh Zonouzi |
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| Institution: | 1. School of Chemistry, College of Science, University of Tehran, Tehran, Iran;2. Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran;3. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran |
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| Abstract: | 1,2,3-Triazole-3-oxoisoindoline-1-carboxamide system was successfully synthesized by using a combination of Ugi and click reactions. This two-step, one-pot synthesis was started by the reaction of 2-formyl benzoic acid, propargyl amine, and cyclohexyl isocyanide in ethanol. The resultant Ugi adduct underwent a copper-catalyzed click reaction, producing the desired products in good yields. |
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| Keywords: | Click reaction multicomponent reaction one-pot synthesis 1 2 3-triazole Ugi reaction |
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