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Efficient and rapid synthesis of phenolic analogs of 4-phenylbutanoic acid using microwave-assisted Michael addition as a key reaction |
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| Authors: | Hirokazu Iida Yusuke Akatsu Kazushi Mizukami Sho Natori Minako Matsukawa Kie Takahashi |
| Affiliation: | 1. Department of Biosciences, Kanto Gakuin University College of Science and Technology, Yokohama, Kanagawa, Japanhiida@kanto-gakuin.ac.jp;3. Department of Biosciences, Kanto Gakuin University College of Science and Technology, Yokohama, Kanagawa, Japan |
| Abstract: | The addition of phenols to acrylonitrile in the presence of aqueous benzyltrimethylammonium hydroxide or tetramethylammonium hydroxide under microwave irradiation yielded the corresponding Michael adducts. The obtained adducts were easily transformed to phenolic analogs of 4-phenylbutanoic acids via the hydrolysis of nitrile groups. |
| Keywords: | Michael addition microwave irradiation 4-PBA |