Dinuclear copper(I) complexes of N-methylbenzothiazole-2-thione: synthesis,structures, antibacterial activity and DNA interaction |
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| Authors: | D Varna T Choli-Papadopoulou R Papi A G Hatzidimitriou |
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| Institution: | 1. Laboratory of Inorganic Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki, Greece;2. Laboratory of Biochemistry, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki, Greece |
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| Abstract: | Three copper(I) halide complexes containing N-methylbenzothiazole-2-thione (mbtt) and triphenylphosphine (PPh3) have been prepared and structurally characterized by X-ray single-crystal analysis. Copper(I) halide precursors CuΧ(PPh3)]4 (X = Cl, Br, I) react with mbtt in 1 : 4 M ratio to give complexes of formula CuΧ(mbtt)(PPh3)]2. Hereby, dimerization is achieved in case of copper(I) chloride and bromide via halide bridges, while copper(I) iodide gives the binuclear thione-S-bridged dimer. The new complexes show moderate in vitro antibacterial activity against certain bacterial strains. The interaction of the compounds with calf-thymus DNA was monitored via UV–vis spectroscopy, DNA-viscosity measurements and their competition with ethidium bromide for the DNA intercalation sites studied by fluorescence emission spectroscopy. Intercalation was revealed as the probable mode of binding. |
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| Keywords: | Copper(I) N-methylbenzothiazole-2-thione crystal structures antimicrobial activity interaction with DNA |
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